161 S. Spruce Avenue | Flexible Floor Plans | 2,000 – 10,000 SF Available

Position your business for success in the heart of South San Francisco. 161 S. Spruce offers a professional environment ideally suited for medical, dental, or office use with customizable layouts to fit your needs.

 Suites available from 2,000 SF to 10,000 SF Lease options for individual suites, full floors, or the entire building Modern professional setting with excellent natural light Convenient access to Highway 101, I-280, SFO Airport, and BART/Caltrain Ample parking and nearby amenities for staff and clients Ideal for healthcare providers, private practices, and professional offices

This is a rare opportunity to secure flexible, high-quality space in a prime location on the Peninsula.

 Contact us today to schedule a tour and discover how 161 S. Spruce can elevate your business.